What would be interesting is to have Bond start to fall for whoever the new Bond girl is, then break it off or just postpone it until he's dealt with his feelings. Of course, it'd be weird to have a recurring girlfriend/friend with benefits in the Bond movies...

Maybe end the movie with Bond and the new girl ending their short-term relationship (after your standard recuperation/vacation time), with Bond accepting another mission and the woman saying goodbye to him.

One thing's for sure, there's a lot of interesting ways for a post-Vesper Bond to go.